Himachal Newsline
Tuesday, May 30, 2023
No Result
View All Result
  • Home
  • Himachal Pradesh News
  • India
    • National
    • State News
  • World
  • Business
  • Education
  • Entertainment
  • Lifestyle
    • Health & Fitness
    • Fashion & Beauty
    • Travel
    • Food
    • Photography
  • Tech
    • App News
  • Auto
  • Others
    • Sports
    • Agriculture
    • Science
    • Astrology
    • Finance/Money
    • Press Release
    • Social Work
    • Religion
Himachal Newsline
No Result
View All Result

Opioid addiction treating drug may be repurposed for type 2 diabetes

Himachal Newsline Desk by Himachal Newsline Desk
November 3, 2020
in Health & Fitness
0 0
0
Share on FacebookShare on Twitter

New Delhi: India is the diabetic capital of the world as every sixth person with diabetes in the world is an Indian. Insulin resistance has been a big challenge for researchers who seek to understand and treat it. Researchers from the Indian Institute of Technology, Mandi (IIT Mandi) have unraveled the mechanism by which insulin overload in the body causes insulin resistance that is associated with diabetes. They have found the drug that is used in treating opioid addiction can potentially reverse this phenomenon.

“We’ve known that one of the causes of insulin resistance is inflammation”, says Dr Prosenjit Mondal, Associate Professor, School of Basic Sciences, IIT Mandi, “We wanted to find out if and how hyperinsulinemia (excess insulin traversing the bloodstream) invokes inflammation in the body, which would provide the link between the two conditions,” he told.

RelatedPosts

SAKRA World Hospital launches the SAKRA Information Centre in Bardhaman, West Bengal

SAKRA World Hospital launches the SAKRA Information Centre in Bardhaman, West Bengal

May 9, 2023
Sharp Sight goes above and beyond for employees with ESOP offering

Sharp Sight goes above and beyond for employees with ESOP offering

April 25, 2023

The relationship between insulin resistance and hyperinsulinemia is cyclic – each increases the occurrence of the other. While it is obvious how insulin resistance leads to hyperinsulinemia – when cells cannot use the insulin, it just remains in the blood – the converse of how hyperinsulinemia increases insulin resistance has hitherto remained unclear.

The Indian Institute of Technology, Mandi (IIT Mandi) have unravelled the mechanism by which insulin overload in the body causes insulin resistance that is associated with diabetes.

The researchers identified a critical protein molecule – SIRT1 which is repressed in hyperinsulinemia. They discovered that a decrease in SIRT1 activates another protein called NFkB, which instigates inflammation, thus providing the link between hyperinsulinemia and systemic inflammation. The team has also discovered a solution to this problem. The researchers found that low-dose naltrexone (LDN), a drug commonly administered for opiate addiction, can activate SIRT1, thereby reducing inflammation and increasing insulin sensitivity of cells.

The significance of this discovery is enormous. “Naltrexone at low doses could potentially restore some of the diabetes-associated events in cellular and animal models”, observed Dr Mondal, who is confident that this is a viable path to follow for Type-2 diabetes management. Naltrexone is already an FDA-approved drug that is used for the treatment of opioid addiction and can easily be repurposed for inflammation reduction and diabetes control. The research team intends to study this thread further, to understand the mechanistic aspects of LDN’s effects on hyperinsulinemia-induced inflammation and resulting insulin resistance.

The study has been carried out with grant support from the Science and Engineering Research Board (SERB). The research team comprised Dr. Prosenjit Mondal, Abhinav Choubey, Khyati Girdhar from IIT Mandi, Dr. Debabrata Ghosh, Aditya K. Kar, and Shaivya Kushwaha from CSIR- Indian Institute of Toxicology Research, Lucknow and Dr. Manoj Kumar Yadav from SRM University, Delhi-NCR, Sonipat, Haryana. The research findings have recently been published in the Journal of Biological Chemistry. (India Science Wire)

Tags: diabetesIIT MandiIndian Institute of Technology
Previous Post

Surat IntStu Aspirations celebrates Halloween in full fledge

Next Post

With a mission in fitness and health, Chakra helps to provide Indians with a unique spinning experience

Himachal Newsline Desk

Himachal Newsline Desk

Related Posts

SAKRA World Hospital launches the SAKRA Information Centre in Bardhaman, West Bengal
Health & Fitness

SAKRA World Hospital launches the SAKRA Information Centre in Bardhaman, West Bengal

May 9, 2023
Sharp Sight goes above and beyond for employees with ESOP offering
Health & Fitness

Sharp Sight goes above and beyond for employees with ESOP offering

April 25, 2023
Japan-based Toyota Tsusho Corporation and Tokai Corp Partner to Launch Valabhi Hospital Services
Health & Fitness

Japan-based Toyota Tsusho Corporation and Tokai Corp Partner to Launch Valabhi Hospital Services

March 20, 2023
Do rare Diseases account for the economic burden on India?
Health & Fitness

Do rare Diseases account for the economic burden on India?

March 20, 2023
zPlus.care for all your healthcare needs
Health & Fitness

zPlus.care for all your healthcare needs

March 17, 2023
Narayana Health’s multi-location campaigns emphasize on Awareness and honour the spirit of Cancer Survivors
Health & Fitness

Narayana Health’s multi-location campaigns emphasize on Awareness and honour the spirit of Cancer Survivors

March 1, 2023
Next Post

With a mission in fitness and health, Chakra helps to provide Indians with a unique spinning experience

Tyre, auto, transport business’ help IPL 2020 Season ride to success

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Recent Posts

  • “TAVVAI”: A Mythological tale of Misfortune and Redemption!!!!! May 29, 2023
  • The User-friendly Interface of FairPlay Makes Betting Convenient for both Newcomers and Seasoned Players May 29, 2023
  • Kashiyana Foundation organize 7th Foundation Day at India International Center, Delhi May 29, 2023
  • Unprecedented 24 years of Annual Sikh Youth Symposium in Bakersfield, California May 26, 2023
  • In a journey of healing and meditation, Anant Oorja Safar bags the ‘Most Promising Spiritual Organization Award’ May 25, 2023

Categories

  • Agriculture (11)
  • App News (13)
  • Astrology (3)
  • Auto (16)
  • Business (465)
  • Education (108)
  • Entertainment (161)
  • Fashion & Beauty (34)
  • Finance/Money (25)
  • Food (17)
  • Himachal Pradesh News (1)
  • India (2)
  • Lifestyle (439)
    • Health & Fitness (170)
    • Photography (5)
    • Travel (25)
  • National (121)
  • Politics (3)
  • Press Release (13)
  • Religion (7)
  • Science (94)
  • Social Work (34)
  • Sports (41)
  • State News (70)
  • Tech (62)
  • World (13)

Categories

  • Agriculture
  • App News
  • Astrology
  • Auto
  • Business
  • Education
  • Entertainment
  • Fashion & Beauty
  • Finance/Money
  • Food
  • Health & Fitness
  • Himachal Pradesh News
  • India
  • Lifestyle
  • National
  • Photography
  • Politics
  • Press Release
  • Religion
  • Science
  • Social Work
  • Sports
  • State News
  • Tech
  • Travel
  • World

Recent News

  • “TAVVAI”: A Mythological tale of Misfortune and Redemption!!!!!
  • The User-friendly Interface of FairPlay Makes Betting Convenient for both Newcomers and Seasoned Players
  • Kashiyana Foundation organize 7th Foundation Day at India International Center, Delhi
  • Unprecedented 24 years of Annual Sikh Youth Symposium in Bakersfield, California
  • In a journey of healing and meditation, Anant Oorja Safar bags the ‘Most Promising Spiritual Organization Award’
  • About Us
  • Advertise
  • Contact Us
  • DMCA
  • Follow on Google News

© 2022 Himachal Newsline

No Result
View All Result
  • About Us
  • Advertise
  • Contact Us
  • DMCA
  • Home
  • Privacy Policy

© 2022 Himachal Newsline

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In