Himachal Newsline
Monday, January 30, 2023
No Result
View All Result
  • Home
  • Himachal Pradesh News
  • India
    • National
    • State News
  • World
  • Business
  • Education
  • Entertainment
  • Lifestyle
    • Health & Fitness
    • Fashion & Beauty
    • Travel
    • Food
    • Photography
  • Tech
    • App News
  • Auto
  • Others
    • Sports
    • Agriculture
    • Science
    • Astrology
    • Finance/Money
    • Press Release
    • Social Work
    • Religion
Himachal Newsline
No Result
View All Result

Opioid addiction treating drug may be repurposed for type 2 diabetes

Himachal Newsline Desk by Himachal Newsline Desk
November 3, 2020
in Health & Fitness
0 0
0
Share on FacebookShare on Twitter

New Delhi: India is the diabetic capital of the world as every sixth person with diabetes in the world is an Indian. Insulin resistance has been a big challenge for researchers who seek to understand and treat it. Researchers from the Indian Institute of Technology, Mandi (IIT Mandi) have unraveled the mechanism by which insulin overload in the body causes insulin resistance that is associated with diabetes. They have found the drug that is used in treating opioid addiction can potentially reverse this phenomenon.

“We’ve known that one of the causes of insulin resistance is inflammation”, says Dr Prosenjit Mondal, Associate Professor, School of Basic Sciences, IIT Mandi, “We wanted to find out if and how hyperinsulinemia (excess insulin traversing the bloodstream) invokes inflammation in the body, which would provide the link between the two conditions,” he told.

RelatedPosts

‘Sassiest’ – Women-Led Sexual Wellness Startup to the Win – Bags the Award for Disruption

‘Sassiest’ – Women-Led Sexual Wellness Startup to the Win – Bags the Award for Disruption

January 18, 2023
Sakal Group’s expert endeavor ‘Swasthyam’ spells out ways to be happy & healthy in life

Sakal Group’s expert endeavor ‘Swasthyam’ spells out ways to be happy & healthy in life

December 17, 2022

The relationship between insulin resistance and hyperinsulinemia is cyclic – each increases the occurrence of the other. While it is obvious how insulin resistance leads to hyperinsulinemia – when cells cannot use the insulin, it just remains in the blood – the converse of how hyperinsulinemia increases insulin resistance has hitherto remained unclear.

The Indian Institute of Technology, Mandi (IIT Mandi) have unravelled the mechanism by which insulin overload in the body causes insulin resistance that is associated with diabetes.

The researchers identified a critical protein molecule – SIRT1 which is repressed in hyperinsulinemia. They discovered that a decrease in SIRT1 activates another protein called NFkB, which instigates inflammation, thus providing the link between hyperinsulinemia and systemic inflammation. The team has also discovered a solution to this problem. The researchers found that low-dose naltrexone (LDN), a drug commonly administered for opiate addiction, can activate SIRT1, thereby reducing inflammation and increasing insulin sensitivity of cells.

The significance of this discovery is enormous. “Naltrexone at low doses could potentially restore some of the diabetes-associated events in cellular and animal models”, observed Dr Mondal, who is confident that this is a viable path to follow for Type-2 diabetes management. Naltrexone is already an FDA-approved drug that is used for the treatment of opioid addiction and can easily be repurposed for inflammation reduction and diabetes control. The research team intends to study this thread further, to understand the mechanistic aspects of LDN’s effects on hyperinsulinemia-induced inflammation and resulting insulin resistance.

The study has been carried out with grant support from the Science and Engineering Research Board (SERB). The research team comprised Dr. Prosenjit Mondal, Abhinav Choubey, Khyati Girdhar from IIT Mandi, Dr. Debabrata Ghosh, Aditya K. Kar, and Shaivya Kushwaha from CSIR- Indian Institute of Toxicology Research, Lucknow and Dr. Manoj Kumar Yadav from SRM University, Delhi-NCR, Sonipat, Haryana. The research findings have recently been published in the Journal of Biological Chemistry. (India Science Wire)

Tags: diabetesIIT MandiIndian Institute of Technology
Previous Post

Surat IntStu Aspirations celebrates Halloween in full fledge

Next Post

With a mission in fitness and health, Chakra helps to provide Indians with a unique spinning experience

Himachal Newsline Desk

Himachal Newsline Desk

Related Posts

‘Sassiest’ – Women-Led Sexual Wellness Startup to the Win – Bags the Award for Disruption
Health & Fitness

‘Sassiest’ – Women-Led Sexual Wellness Startup to the Win – Bags the Award for Disruption

January 18, 2023
Sakal Group’s expert endeavor ‘Swasthyam’ spells out ways to be happy & healthy in life
Health & Fitness

Sakal Group’s expert endeavor ‘Swasthyam’ spells out ways to be happy & healthy in life

December 17, 2022
Transcatheter Electrosurgery, Dr Ravinder Singh Rao & Team successfully performs India’s first LAMPOON – Non-surgical heart valve replacement
Health & Fitness

Transcatheter Electrosurgery, Dr Ravinder Singh Rao & Team successfully performs India’s first LAMPOON – Non-surgical heart valve replacement

December 9, 2022
Primus Senior Homes teams up with LiveAltlife to conduct a diabetes awareness session
Health & Fitness

Primus Senior Homes teams up with LiveAltlife to conduct a diabetes awareness session

November 18, 2022
Sakra World Hospital celebrates Children’s Day with a new Sankalp
Health & Fitness

Sakra World Hospital celebrates Children’s Day with a new Sankalp

November 15, 2022
World Laughter Yoga Master Rajendra Kumar continues to make India a happier country with Laughter Yoga
Health & Fitness

World Laughter Yoga Master Rajendra Kumar continues to make India a happier country with Laughter Yoga

September 30, 2022
Next Post

With a mission in fitness and health, Chakra helps to provide Indians with a unique spinning experience

Tyre, auto, transport business’ help IPL 2020 Season ride to success

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Recent Posts

  • Shaping the National Schools with International Accreditation Standards Council for International American Accreditation, New York now launching in India January 30, 2023
  • Basant celebrated at Nizamuddin Dargah: Syed Anis Nizami, Incharge Dargah Sharif January 28, 2023
  • Fan Frenzy, Players Auction at the Silver Oak Cricket Premiere League January 27, 2023
  • Inaugural Yuvamanthan Model G20 Summit held in Goa January 27, 2023
  • Akhil Sachdeva’s love ballad O Sanam featuring Sara Gurpal is the right mix of melody and poetry, hitting home with people across the board January 23, 2023

Categories

  • Agriculture (11)
  • App News (13)
  • Astrology (3)
  • Auto (14)
  • Business (416)
  • Education (100)
  • Entertainment (150)
  • Fashion & Beauty (32)
  • Finance/Money (25)
  • Food (17)
  • Himachal Pradesh News (1)
  • India (2)
  • Lifestyle (416)
    • Health & Fitness (162)
    • Photography (5)
    • Travel (24)
  • National (119)
  • Politics (3)
  • Press Release (5)
  • Religion (3)
  • Science (94)
  • Social Work (32)
  • Sports (35)
  • State News (68)
  • Tech (61)
  • World (10)

Categories

  • Agriculture
  • App News
  • Astrology
  • Auto
  • Business
  • Education
  • Entertainment
  • Fashion & Beauty
  • Finance/Money
  • Food
  • Health & Fitness
  • Himachal Pradesh News
  • India
  • Lifestyle
  • National
  • Photography
  • Politics
  • Press Release
  • Religion
  • Science
  • Social Work
  • Sports
  • State News
  • Tech
  • Travel
  • World

Recent News

  • Shaping the National Schools with International Accreditation Standards Council for International American Accreditation, New York now launching in India
  • Basant celebrated at Nizamuddin Dargah: Syed Anis Nizami, Incharge Dargah Sharif
  • Fan Frenzy, Players Auction at the Silver Oak Cricket Premiere League
  • Inaugural Yuvamanthan Model G20 Summit held in Goa
  • Akhil Sachdeva’s love ballad O Sanam featuring Sara Gurpal is the right mix of melody and poetry, hitting home with people across the board
  • About Us
  • Advertise
  • Contact Us
  • DMCA
  • Follow on Google News

© 2022 Himachal Newsline

No Result
View All Result
  • About Us
  • Advertise
  • Contact Us
  • DMCA
  • Home
  • Privacy Policy

© 2022 Himachal Newsline

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In